Vaccines Lung Cancer

Vaccine for Lung Cancer CIMAvax-EGF

Created by specialists from the Center for Molecular Immunology, the Cimavax-efg therapeutic vaccine against advanced non-small cell lung cancer has been applied in more than 5000 Cuban patients with promising results.

Therapeutic vaccines for lung cancer

Contents of this Page
1- What is the Lung Cancer Vaccine?
2- What patients are candidates?
3- Requirements to opt for the vaccine
4-How is the Vaxira vaccine applied?
5- How is the CIMAvax vaccine applied?
6- Mechanism of action
7- Adverse Reactions

What is the Therapeutic Vaccine for Lung Cancer?

The Therapeutic Vaccine for Lung Cancer is a drug that is applied to patients in stages IIIb and IV to increase their survival.

Most of us are familiar with the use of vaccines to combat certain diseases such as the flu, chicken pox, or measles vaccine. However, the use of therapeutic cancer vaccines may not be a common term. Advances in research and improved diagnostics are enabling the development of a new generation of drugs for treating tumors. Among these new drugs to fight cancer, treatments based on immunotherapies, are offering very promising results.

Therapeutic vaccines use the same mechanism as preventive vaccines, except that their action is to cure or decrease the patient's disease state, increasing their survival through the activation of their immune system.

The basic idea is to mobilize the immune system so that its components, which normally defend you against all kinds of diseases, fight against cancer cells that grow inside the body.

The vaccines for lung cancer CIMAvax-EGFhr and Vaxira offer the possibility of turning advanced cancer into a controllable chronic disease, as it generates antibodies against proteins that trigger uncontrolled cell proliferation processes.

The action of the treatment of vaccines for lung cancer is based on active immunotherapy; that is, it manipulates the immune response of an individual so that it generates its own antibodies.

It is important to emphasize to keep in mind that the vaccine does not prevent the disease like a traditional vaccine; its action is to prevent lung cancer tumors from developing, acting more like a treatment. It is known, therefore, as a therapeutic vaccine. Rather than targeting cancer cells directly, the vaccine acts as a form of immunotherapy.

It is not a curative drug, but it stabilizes the tumor and leads the disease to chronic non-communicable pathology.

Which patients are candidates for treatment with lung cancer vaccines?

Treatment for lung cancer with the CIMAvax-EGFhr or Vaxira vaccines is indicated in those patients who meet certain requirements or conditions such as:

  •     That the patient is older than 18 years
  •     Carriers of non-small cell lung tumors.
  •     Patients in advanced stages of the disease (IIIb and IV).
  •     Have completed the first line of cancer-specific therapy.
  •     That the tumor originated in the lung.
  •     That it does not have metastasis to the brain.
  •     others

Consult other requirements or conditions to opt for this vaccine

IMPORTANT

TO HAVE A QUICK AND EFFECTIVE RESPONSE, WE RECOMMEND THAT YOU READ CAREFULLY THE REQUIREMENTS SO THAT THE PATIENT IS ACCEPTED AND MAKES SURE THAT THE PATIENT COMPLIES WITH THEM, ALSO DO NOT CONTACT US EVEN WHEN THE PATIENT DOES NOT RECEIVE THE REQUIREMENTS. THAT IMPROVES YOUR QUALITY OF LIFE IN CASE YOU ARE NOT CANDIDATE FOR TREATMENT WITH THE THERAPEUTIC VACCINE FOR LUNG CANCER.

It is not necessary for the patient to travel to seek treatment, a family member or friend can do it, but first it is essential to send all the evaluation they have and that the medical team approve their application.

THE MEDICATION DURING THE TRIP TO YOUR COUNTRY MUST BE KEPT COLD, SO WE SUGGEST YOU BRING A THERMAL BAG AND GEL TO FREEZE.

How is the Lung Cancer Vaccine given?

Previously, the patient must give their consent in writing

Treatment with Vaxira is applied in two Stages:

Induction phase
The first five doses will be given 14 days apart. (Days: 0, 14, 28, 42, 56). Compliance with this stage is important to achieve a good level of seroconversion and immunogenicity of the vaccine.
Maintenance phase
One dose is administered every 28 days, until the patient has unacceptable toxicity or deterioration in general condition.
The progression of the disease, both symptomatic and radiological, is not a criterion for interrupting vaccination
The vaccines are given to the muscles of the arms and buttocks in the morning. We have chosen Monday to apply this type of treatment.
The Vaxira® Therapeutic Vaccine is administered intradermally. Each time you are vaccinated, each dose will be divided into 4 small injections given at 4 different sites on the body, which can be arms and legs.

Treatment with CIMAvax is applied in two stages:

Induction phase
Treatment consists of an induction phase that begins with the administration of cyclophosphamide (single dose of 200 mg / m2).
Each injection contains 1.2 mL of the emulsion containing hrEGF-rP64k conjugate and Montanide ISA 51 VG
Three days later, the administration of CIMAvax-EGF® is started, every 14 days during the first four doses.
Maintenance phase
This phase includes monthly re-immunizations (every 28 days) that will be maintained until the general condition of the patient allows it.
The CIMAvax-EGF vaccine is administered intramuscularly and its high level of safety makes it easy to use it at the primary health care level.
Afterwards the injection should not be given outside of medical institutions.

Treatment Effectiveness:

The use of the CIMAvax-EGFhr or Vaxira vaccines has prolonged life from six months to five years in diagnosed patients with low life prospects.

Adverse reactions

The side effects are much less than other conventional and more aggressive treatments to fight cancer.
The most frequent adverse events, taking into account the intensity are:
  1. Local: erythema and pain at the injection site (moderate).
  2. Systemic:
  •     Blush (light)
  •     Dry mouth (slight)
  •     Myalgias and arthralgias (slight)
  •     General malaise (slight)
  •     Chills (moderate)
  •     Tremors (moderate), headache

We recommend that the patient not touch the area, massage, or scratch.

Action mechanisms
CIMAvax-EGFhr and Vaxira are immunotherapy treatments for non-small cell lung cancer in advanced stages of the disease, their medical action is different for two membrane receptors that are expressed in the disease.

CimaVax-EFG® is a vaccine composed of EFG conjugated with a carrier protein (carrier) and an adjuvant (Montanide ISA51). This vaccine induces the manufacture of antibodies that bind to the EFG receptor (EFG-R), making the interaction [EFG EFG-R] impossible and in this way the tumor is considerably reduced.

Racotumomab (Vaxira) is an IG1 isotype murine anti-idiotic monoclonal antibody raised against Mab P3. It recognizes mAb P3 and specifically inhibits its binding to N-glycolylated gangliosides, in particular to the NeuGcGM3 ganglioside, which is a tumor-specific antigen. The NeuGcGM3 ganglioside is expressed in different types of tumor cells.

Immunization of patients with non-small cell lung tumors (NSCLC) with the VAXIRA® vaccine induces the production of IgG and IgM isotype-specific Ab3 antibodies against the NeuGcGM3 ganglioside, capable of recognizing this antigen and causing the lysate. of the tumor surface (antibodies with cytotoxic capacity).

Although both vaccines for lung cancer have the same indication, their mechanisms of action are different: CIMAvax EGF arrests circulating EGF - epidermal growth factor - in blood and VAXIRA acts on a specific tumor antigen called Nglycolylated ganglioside - NGcM3, through of an immune network of idiotypes. These are different mechanisms on which drugs targeting EGFR mutations, or ALK alterations, act.

 

Vaccines for Lung Cancer
CIMAvax-EGFhr and Vaxira
Therapy for Lung Cancer with Monoclonal Antibodies
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